I had similar issue after upgrading the client (ubuntu command line) to "v0.4.21-RC1" last night, thinking that it may help with EXPIRED transactions issue I had with the pool.
https://bitsharestalk.org/index.php?topic=6236.msg136549#newOn upgrade I was unable to wallet_transfer to any of the numerous local accounts from any of the wallets registered accounts.
As I use local accounts as a way to transfer pool payments to BTSX account keys this was a critical issue for me, so I rolled back the client version and re-synced just to get these payments out.
I haven't yet tried again with the new "v0.4.21", will let you know if OK tonight.
I have the client wallet folder logs if it turns out there is an issue and someone needs them - let me know.
./bitshares_client --version
{
"blockchain_name": "BitShares X",
"blockchain_description": "Decentralized Autonomous Exchange",
"client_version": "v0.4.21-RC1",
"bitshares_toolkit_revision": "34650324eba1025bd46929576db6621502f89fef",
"bitshares_toolkit_revision_age": "34 hours ago",
"fc_revision": "307252e23adfb43b41a6a4ff5683c72f86c0083a",
"fc_revision_age": "43 hours ago",
"compile_date": "compiled on Oct 22 2014 at 14:35:19",
"boost_version": "1.54",
"openssl_version": "OpenSSL 1.0.1f 6 Jan 2014",
"build": "linux 64-bit"
}